Cell Being: The Dual Benefits of Longevity and Weight Loss

August 13, 2024

Cell Being is formulated to target the root causes of aging, but many users have reported weight loss and improved body composition after using it for some time. While this was an unexpected side effect, it led us to ask, 'How are the ingredients in Cell Being working within the body to produce these benefits?' In this article, you’ll learn about how our research-backed ingredients help boost metabolism, increase energy, and support fat loss.

Research Backed Ingredients

Nicotinamide Mononucleotide (NMN)

In recent years, NMN has been labeled, ‘The Fountain of Youth’ for its promising effects on combating age-related conditions. It is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential molecule necessary for enzymes to perform their functions - it is the energy that powers all of the cells in every single organism. It regulates DNA repair, metabolism, energy production, stress response, and so on. NMN enters the cell, and directly converts into NAD+, increasing NAD+ levels in the blood, organs, and muscles. By increasing NAD+, a myriad of benefits occur, including increased metabolism, leading to enhanced fat loss. Let’s dig into the research.

Research Insights: NMN’s Impact on Metabolism and Obesity

Studies on NMN supplementation have investigated its impact on different areas of metabolism and physiological processes. In one study, researchers explored the effects of NMN supplementation on obese mice, highlighting a reduction in fat mass and increase in lean mass [1]. The treatment improved glucose tolerance, lowered blood lipid levels, and reduced liver fat, though it didn't significantly change insulin sensitivity [1]. NMN also promoted the browning of white fat and increased thermogenesis in brown fat, which are processes that help burn fat [1]. The study suggests that NMN regulates fat metabolism through the NAD+/SIRT6/LKB1 pathway, contributing to these beneficial effects on obesity and metabolism [1]. These findings found that NMN supplementation led to higher levels of two key enzymes: lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL) [1]. These enzymes play a crucial role in breaking down fats in the body. As a result of the increased enzyme activity, more fat was broken down, a process known as lipolysis. Essentially, NMN helps to enhance the body's ability to burn fat by boosting the activity of these enzymes.

NMN’s Influence on Lifespan and Health

Another study investigated the long-term effects of NMN supplementation on the health and lifespan of male and female mice. The researchers found that NMN slowed the accumulation of adipose (fat) tissue in male mice as they aged, leading to better metabolic health. Interestingly, female mice experienced an 8.5% increase in median lifespan, possibly due to how NMN affects NAD+ metabolism differently between sexes. Additionally, NMN reduced frailty in both sexes, possibly linked to changes in gut bacteria that lower inflammation [2].

Detailed Mechanistic Insights

Moreover, another animal study examined how NMN affects fat cells and found that NMN boosts the expression of a key fat-breaking enzyme called ATGL (adipose triglyceride lipase) through the SIRT1-AMPK signaling pathway. ATGL plays a crucial role in breaking down fat, and its increased activity leads to enhanced lipolysis. The study also showed that NMN treatment reduced fat buildup in subcutaneous (under the skin) fat tissue but not in the deeper epididymal fat tissue, suggesting NMN has a site-specific effect on fat reduction [3]. This highlights NMN's beneficial effects on metabolism and potential to enhance the breakdown of triglycerides into fatty acids, thereby promoting fat breakdown and positively impacting overall metabolic health.

The Role of NMN in Thermogenesis
One study investigated the role of NAD+ in regulating the energy metabolism and thermogenic (heat-producing) functions of fat tissues, particularly focusing on brown adipose tissue (BAT) and white adipose tissue (WAT). It showed cold exposure triggers an increase in NAD+ production in both brown and white adipose tissues, largely driven by the enzyme NAMPT. This enzyme's activity is crucial for maintaining optimal NAD+ levels, which in turn regulate critical proteins, essential for the thermogenic function of brown adipose tissue (BAT) [4].

When NAMPT is absent, NAD+ levels decrease, leading to a disruption in the gene programs necessary for effective thermogenesis and mitochondrial function, especially in BAT. Additionally, in white adipose tissue (WAT), diminished NAD+ levels impair the breakdown of fats, a key process needed for heat generation. Notably, the study also finds that NAD+ levels, along with NAMPT expression, rise in humans during cold exposure, suggesting a similar mechanism at play in regulating energy and heat production across species [4].

Supplementation with nicotinamide mononucleotide (NMN), a precursor to NAD+, has been shown to effectively restore these disrupted metabolic processes. By boosting NAD+ levels, NMN reactivates essential pathways for energy production and heat generation in adipose tissues, highlighting its potential as a therapeutic agent for enhancing fat tissue function and the body's overall energy balance [4].

Growing Research
The growing body of research surrounding NMN supports its role in enhancing metabolic health. By boosting NAD+ levels, NMN not only improves fat metabolism and energy production but also influences broader physiological processes crucial for aging and disease resistance. Studies demonstrate its ability to regulate fat breakdown, improve body composition, and enhance cellular energy efficiency in both animal models and potentially in humans.

Resveratrol

Research shows that resveratrol, a natural polyphenol found in a variety of plants, may have beneficial effects on metabolism and body weight.

Clinical Evidence of Resveratrol's Efficacy

For instance, in a randomized double-blind crossover study, over a 30-day period with 11 healthy, obese men receiving either a placebo or 150 mg/day of resveratrol resveratrol supplementation demonstrated similar effects to those of calorie restriction or endurance training [5]. Resveratrol was shown to safely enhance fat metabolism and overall metabolic health without any reported adverse effects. The resveratrol group led to improved mitochondrial function in muscles, reduced systemic metabolic rate, and lower energy expenditure, pointing to increased metabolic efficiency [5]. Additionally, resveratrol lowered blood pressure, liver fat, and systemic inflammation while enhancing fat oxidation in muscles, which supports improved cardiovascular health and weight management [5].

Molecular Actions of Resveratrol

Key to these benefits, resveratrol activated proteins like AMPK, SIRT1, and PGC-1α that boost mitochondrial activity and energy utilization, particularly from fats [5]. This suggests that resveratrol could help shift the body's energy use from sugars to fats, a desirable trait in managing obesity and metabolic syndrome. Moreover, it reduced systolic blood pressure and improved vascular function, reinforcing its potential cardiovascular benefits [5].

Human Studies on Resveratrol and Weight Loss

Another study in humans provided some insights into resveratrol’s weight loss effects. In a 26-week study focused on the effects of resveratrol supplementation, significant body fat reduction was observed among older adults [6]. Participants who were administered 200 mg/day of resveratrol experienced a noticeable decrease in body fat compared to those given a placebo [6]. This reduction was also associated with an increase in leptin levels, a hormone that helps regulate energy balance by inhibiting hunger [6].

Weight and fat loss are influenced by the process of mitochondrial biogenesis, which can be enhanced by resveratrol. It activates SIRT1, an enzyme integral to cellular health and metabolism [7]. SIRT1, in turn, activates PGC-1α, a crucial regulator that drives genes responsible for energy metabolism and mitochondrial function [8]. By promoting mitochondrial biogenesis, resveratrol helps cells increase their energy expenditure, thereby facilitating more effective fat burning and weight loss.

Animal Research Supporting Resveratrol's Effects

An animal study explored the effects of resveratrol on mice fed either standard or high-fat diets [9]. The findings revealed significant benefits, including increased resistance to obesity induced by a high-fat diet and enhanced aerobic capacity [9]. This improvement in physical endurance was evidenced by longer running times and greater oxygen consumption in muscle fibers [9].

Despite consuming similar amounts of food as the control group, the treated mice showed reduced body fat and enhanced resistance to obesity and insulin resistance [9]. Additionally, changes in mitochondrial structure and an increase in UCP-1 protein, which aids in heat production in brown adipose tissue, led to increased energy expenditure and protection against weight gain [9].

Implications for Obesity Management

Moreover, the resveratrol-treated mice showed increased resistance to cold environments, likely due to enhanced mitochondrial activity in their brown adipose tissue, which did not lead to compensatory increases in food intake [9]. This indicates that resveratrol effectively disrupts the typical energy balance feedback mechanism, preventing the mice from eating more despite higher energy expenditure. Such findings highlight resveratrol's potential as an effective component in anti-obesity treatments, offering an approach that does not require reduced caloric intake to achieve weight loss.

TMG

TMG, or trimethylglycine, also known as betaine, is naturally produced by the body and found in foods such as beetroot, wheat, quinoa, and seafood [10]. Animal studies have indicated that TMG supplementation can help reduce body fat. However, results from human studies have been mixed and inconsistent.

Review of TMG Supplementation in Humans

To address these discrepancies, a systematic review and meta-analysis was conducted, focusing on the effects of TMG supplementation on human obesity. This analysis reviewed data from randomized controlled trials, including six studies with a total of 195 participants [11].

Results of the Meta-Analysis

The findings revealed that TMG supplementation had a significant effect on reducing total body fat mass and body fat percentage [11]. Specifically, the average reduction in body fat mass was 2.53 kg and the reduction in body fat percentage was 2.44% [11]. Both measures showed low heterogeneity among the studies, indicating that the results were consistent across different studies.

Insights into Weight and BMI Impact

However, the review found no significant changes in overall body weight or body mass index (BMI) [11]. The changes in body weight were minimal and the changes in BMI were also negligible, with both measurements showing no statistical heterogeneity [11].

The analysis concluded that while betaine supplementation might not significantly affect body weight or BMI, it appears to be effective in reducing body fat mass and percentage [11]. This suggests that dietary betaine could be considered as a viable supplement for specifically targeting body fat reduction in obesity treatments.

Conclusion

In conclusion, Cell Being, initially formulated to address the root causes of aging, has also shown potential in supporting metabolic health. Users have reported benefits such as weight loss and improved body composition, which were initially unexpected. Our formula includes NMN, trans-resveratrol, and TMG. NMN helps boost NAD+ levels and enhance energy metabolism. Resveratrol supports fat metabolism and cardiovascular health by mimicking the effects of calorie restriction and enhancing mitochondrial function. Additionally, TMG has shown its potential to reduce body fat, reflecting our commitment to incorporating synergistic ingredients that are backed by scientific research. Together, these ingredients in Cell Being support not only longevity but also metabolic health, specifically fat/weight-loss, making it a versatile supplement for overall health.