VERSO CLEAN BEING
VERSO CLEAN BEING
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Ingredients
Ingredients
Per 2 capsules:
Spermidine - 6mg
Luteolin - 250mg
Dihydroquercetin - 50mg
How to use
How to use
We recommend taking Clean Being with or without a meal.
Shipping
Shipping
Free Shipping on US orders. International shipping with duties and taxes prepaid is available to select countries for reasonable rates.
Return policy
Return policy
We 100% guarantee that you will receive what you bought – if not we will make it right. This means that the products will be intact, and the contents will match the label.
Read more here.
US made
US made
We manufacture in a GMP compliant and FDA registered facilities in the US.
WTF is Autophagy?
Autophagy is a process that occurs within cells to help them clean up and recycle their own components. Imagine that you are cleaning out your closet or garage - you might come across items that are broken or no longer useful, and you might decide to throw them away or recycle them. Autophagy is similar, but it happens inside cells. The cell is able to identify and remove damaged or unnecessary proteins, organelles, and other molecules, and recycle them or break them down into their component parts. This process helps the cell to maintain its normal functioning and can also be activated in response to stress, such as when the cell is running low on energy.
Autophagy plays an important role in maintaining the health of the cell and the body as a whole, and impairment of autophagy has been implicated in a number of diseases, including neurodegenerative disorders, cancer, and infectious diseases.
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Oxidative Stress
As we age, it becomes increasingly important to maximize our cellular health, and ensure our cells are functioning optimally – after all, our body is made up of trillions of cells that form our tissues, which form our organs, and which dictate many facets of our overall health. Unfortunately, cells often go awry due to disease, the aging processes, oxidative stress and environmental exposures: our diet, lack of nutrients, lack of oxygen, any exposure to toxins, and much more. Cellular damage can lead to chronic inflammation and accelerated aging.
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Promoting Autophagy
The promotion of cellular health and clean-up is necessary to slow the processes of aging, as well as to prevent chronic inflammation and the development of disease. In promoting optimal cellular health it is important to promote proper regulation of autophagy, apoptosis, mitophagy, and mitochondrial biogenesis as well as to prevent long-term oxidative stress which causes cellular damage, dysfunction and inflammation.
CLEAN BEING
Formulated with evidence-based ingredients to promote natural clean up processes like autophagy and apoptosis to support healthy aging, and help prevent chronic inflammation and the development of diseases.
Spermidine 🌾
Dihydroquercetin 🥦
Luteolin 🥬
Formulated to support
BENEFITS BEYOND CELLULAR CLEAN UP
Autophagy
Spermidine has been shown to induce autophagy.
10.4161/15384101.2014.973309
Evidence suggests that in animal models of Alzheimer’s disease(AD) and cancer, quercetin is able to induce cellular autophagy, the body's process of clearing out damaged cells.
10.3390/ijms21020493
Heart
Spermidine levels related to dietary uptake have been shown to protect from cardiac aging.
In a human cohort, a higher combined dietary intake of spermidine and spermine correlated with a lower rate of cardiovascular disease. After spermidine supplementation, individuals in the higher tertile of spermidine intake also had lower blood pressure
10.1038/nm.4222
A meta-analysis showed that lower spermidine and spermine levels were associated with higher cardiovascular disease-related mortality rate.
10.5539/gjhs.v4n6p170
Several studies have found that luteolin supports heart health. Studies in mice have shown that luteolin strengthens heart cells and heart contractions.
10.1371/journal.pone.0082957
PMID: 2172327
Luteolin was found to reduce oxidative stress-induced damage during a simulated heart attack in the isolated hearts of mice.
https://doi.org/10.1007/s11655-015-2296-x
In a human study, quercetin lowered LDL oxidation, increased levels of which are associated with coronary heart disease, amongst male participants.
10.1016/j.imbio.2010.07.011
Research including hypertensive human participants suggests that quercetin is able to reduce blood pressure, thereby supporting cardiovascular health.
10.1093/jn/137.11.2405
Dihydroquercetin has been shown to promote heart health in healthy human volunteers via lowering LDL cholesterol.
https://doi.org/10.1016/j.ejphar.2012.03.035
Brain
In several animal and organism models, supplementation with spermidine has been shown to protect against neurodegeneration.
10.1172/JCI73944
10.1038/nature05292
In mice, spermidine was also shown to reduce dementia (in a mouse model of frontotemporal lobar dementia).
10.1073/pnas.1206362109
Across various animal and cell studies, luteolin has been shown to have neuroprotective effects and to support nerve development. This effect is likely due to luteolin’s ability to reduce glutamate levels, suppress brain inflammation and deter oxidative stress. These benefits support hippocampal neuron growth and prevent the mutation of neural proteins.
Inflammation
In animal studies, luteolin has been shown to prevent inflammation of the lungs, nose and brain via the inhibition of pro-inflammatory cytokines.
In mice, luteolin also prevents viral-induced inflammation in the breast and lung.
Quercetin and its derivatives ability to fight inflammation, as well as to activate NrF2, increase glutathione levels, and scavenge free radicals, is one of its main mechanisms of conferring health benefits.
https://doi.org/10.5114/ceji.2017.67315
doi:10.18632/oncotarget.16092
https://doi.org/10.1016/j.neuro.2016.05.008
https://doi.org/10.1016/j.brainresbull.2015.09.002
Immunity
Luteolin supplementation has been shown to enhance the immune system in various ways. In animal studies, luteolin blocks lipopolysaccharide-induced (LPS) inflammation which is associated with bacterial infection.
Luteolin has also been found to inhibit viral spread in mice, including both Epstein-Barr and hepatitis B . A cell study also supports this evidence, suggesting that luteolin has antiviral capacities against Japanese encephalitis virus.
https://doi.org/10.1007/978-90-481-9078-2_1
PMID:11123379
https://doi.org/10.2174/138161206778743565
https://doi.org/10.1164/ajrccm.165.6.2101049
https://doi.org/10.1016/j.antiviral.2016.05.007
https://doi.org/10.18632/oncotarget.7967
https://doi.org/10.1021/acs.molpharmaceut.5b00789
Lifespan
In animal and organism models, spermidine supplementation extends lifespan.
10.1038/ncb1975
PMID: 28407698
10.1083/jcb.201008167
10.1038/cdd.2016.71
One study showed that in several Asian countries, the amount of polyamine uptake via food is correlated with life expectancy, however confounding factors in this study were not adequately adjusted for.
10.4236/health.2010.212206
In nonagenarians(90-99 y.o) and centenarians, an increase in levels of whole-level spermidine is linked to longevity.
PMID: 22950434
When blood levels of spermidine are increased in aged mice via supplementation of polyamine-producing probiotic bifidobacteria, decreased mortality is observed.
10.1038/srep04548
10.1371/journal.pone.0023652
Weight
In a study, spermidine was shown to reduce weight gain and certain risk factors of obesity.
10.1038/cddis.2017.373
Hair
In multiple studies, spermidine has been shown to improve hair growth, hair follicle number and hair follicle health in ‘hair follicle epithelial stem cells in serum-free organ culture’.
10.1371/journal.pone.0022564
https://doi.org/10.5826/dpc.0704a05
Skin
Animal research has found that luteolin may reverse skin aging and prevent the development of skin cancer. This effect is likely due to the antioxidative properties of luteolin, which protect the skin from sun damage.
https://doi.org/10.1111/jcmm.12050
https://doi.org/10.1158/0008-5472.CAN-09-4093
Muscle
In aged mice, spermidine administration was able to prevent the senescence of muscle stem cells, improve muscle regeneration, and inhibit muscle atrophy.
PMID:28407698
10.1038/nature16187
In collagen-deficient mice, spermidine aided with improving muscle defects.
10.1080/15548627.2015.1108508
In mice quercetin supplementation has been shown to reduce muscle mass atrophy.
https://doi.org/10.1155/2014/83429
In a human study with young athletes, quercetin supplementation increased muscle mass.
https://doi.org/10.1186/s12970-019-0303-x
Mitochondria
Overall, spermidine has been shown to improve mitochondria health and structure in both cardiac and skeletal muscles in mice.
10.1080/15548627.2015.1108508
10.1038/nm.4222
PMID: 28407698
10.1038/nature16187
A study in vitro showed that quercetin reduced renal tubular epithelial cell senescence likely via activating SIRT-1 and inducing mitophagy, the beneficial clearing of damaged mitochondria.
https://doi.org/10.1016/j.lfs.2020.118116
In mice, quercetin improves mitochondrial biogenesis in the brain and muscle – therefore quercetin possesses the ability to both clear out damaged mitochondria and stimulate the generation of new functional mitochondria.
https://doi.org/10.1152/ajpregu.90925.2008.
Mimetic
Spermidine is also considered a calorie-restriction mimetic, meaning that it is thought to mimic the health benefits of calorie restriction(CR)(enhanced longevity) by impacting similar mechanisms as CR. One of the main health-promoting mechanisms of CR is autophagy, which clears cells of damage, and is critical for cellular homeostasis as well as preventing cells from going awol.
10.4161/15384101.2014.973309
A POWERFUL COMBINTATION
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Spermidine
It is a polyamine, meaning that it is an organic compound with two or more amino groups. Spermidine plays a crucial role in the survival and function of cells, including supporting cellular growth, DNA health, and apoptosis 💥
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Luteolin
Luteolin is a plant pigment belonging to the flavonoid family. Supplementation with luteolin is believed to confer longevity benefits, as it has multiple biological effects such as anti-inflammation, anti-allergy and anti-cancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically ⭐️
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Dihydroquercetin
A plant flavonoid phytochemical compound derived from quercetin. Dihydroquercetin has higher absorption and bioavailability when compared to quercetin - it is able to enter the bloodstream faster. Research shows that quercetin in part impacts cellular senescence, loss of proteostasis, and mitochondrial dysfunction ⚡️
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Always Tested
We pride ourselves on transparency - we conduct third-party lab tests on all batches we manufacture to validate the ingredients we use are pure. Therefore, offering the highest quality products.
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Cold Storage
We keep our inventory in custom built refrigeration in our warehouse to ensure your product isn't sitting on the shelf for months on end in a hot warehouse, potentially degrading.
FAQ
Why does Clean Being use dihydroquercetin and not regular quercetin?
Dihydroquercetin has higher absorption and bioavailability when compared to quercetin - it is able to enter the bloodstream faster.
What is autophagy?
Autophagy is a cellular clean-up, salvage and recycling mechanism which removes damaged cells (including diseased cells) and cellular parts, in order to promote the proper functioning of cells.
Why is autophagy important?
If autophagy is dysregulated this can lead to oxidative stress, chronic inflammation and disease. As we age, autophagy declines. Therefore, in order to prevent the processes of aging, diseases of aging and to ensure optimal cellular function, supporting proper regulation of autophagy is important.
What is apoptosis?
Apoptosis is a necessary cellular process to end a cell's life; it is known as ‘programmed cell death’.
This built-in cellular process is necessary to eliminate dysfunctional cells and make way for new healthy cells.
Certain pro-aging cells can develop resistance to apoptosis, such as senescent cells (contribute to disease) and cancer cells. Thus, when apoptosis is not effective, dysfunctional cells can replicate and cancer may develop.
Why is apoptosis important?
The dysregulation of cellular death likely accelerates the aging processes. To support healthy apoptosis, look into fasting, and phytochemicals like: luteolin, NMN, resveratrol, spermidine and sulforaphane.
Where are your products made?
We manufacture in an FDA registered and GMP certified facility in the USA.
What about dosage?
We recommend taking 2 capsules a day with food, preferably containing some fat.
Is Clean Being vegan and/or gluten free?
Yes, Clean Being is vegan and gluten free 🌱.
What are some healthy fats I can take my Clean Being capsules with?
We recommend taking Clean Being with moderate fats, as quercetin's bioavailability improves when done so.
Examples include, but are not limited to: avocado, MCT oil, coconut oil, eggs, yogurt, butter, nuts, and salmon.
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