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VERSO CLEAN BEING

VERSO CLEAN BEING

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Spermidine, Luteolin, and Dihydroquercetin - a powerful blend of senolytic molecules that help promote natural clean up processes like autophagy and apoptosis. 

Ingredients

Per 2 capsules:
Spermidine - 6mg
Luteolin - 250mg
Dihydroquercetin - 50mg

How to use

We recommend taking Clean Being with or without a meal.

Shipping

Free Shipping on US orders. International shipping with duties and taxes prepaid is available to select countries for reasonable rates.

Return policy

We 100% guarantee that you will receive what you bought – if not we will make it right. This means that the products will be intact, and the contents will match the label.

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WTF is Autophagy?

Auto [self] - phagy [eat]. Autophagy is a cellular clean-up, salvage and recycling mechanism which removes damaged cells (including diseased cells) and cellular parts, in order to maintain cellular homeostasis and promote the proper functioning of cells.

  • Oxidative Stress

    As we age, it becomes increasingly important to maximize our cellular health, and ensure our cells are functioning optimally – after all, our body is made up of trillions of cells that form our tissues, which form our organs, and which dictate many facets of our overall health. Unfortunately, cells often go awry due to disease, the aging processes, oxidative stress and environmental exposures: our diet, lack of nutrients, lack of oxygen, any exposure to toxins, and much more. Cellular damage can lead to chronic inflammation and accelerated aging.

  • Promoting Autophagy

    The promotion of cellular health and clean-up is necessary to slow the processes of aging, as well as to prevent chronic inflammation and the development of disease. In promoting optimal cellular health it is important to promote proper regulation of autophagy, apoptosis, mitophagy, and mitochondrial biogenesis as well as to prevent long-term oxidative stress which causes cellular damage, dysfunction and inflammation.

CLEAN BEING

Formulated with evidence-based ingredients to promote natural clean up processes like autophagy and apoptosis to support healthy aging, and help prevent chronic inflammation and the development of diseases.

Spermidine 🌾

Dihydroquercetin 🥦

Luteolin 🥬

Formulated to support

BENEFITS BEYOND CELLULAR CLEAN UP

Autophagy

Spermidine has been shown to induce autophagy.
10.4161/15384101.2014.973309

Evidence suggests that in animal models of Alzheimer’s disease(AD) and cancer, quercetin is able to induce cellular autophagy, the body's process of clearing out damaged cells.

10.3390/ijms21020493

Heart

Spermidine levels related to dietary uptake have been shown to protect from cardiac aging.

In a human cohort, a higher combined dietary intake of spermidine and spermine correlated with a lower rate of cardiovascular disease. After spermidine supplementation, individuals in the higher tertile of spermidine intake also had lower blood pressure
10.1038/nm.4222

A meta-analysis showed that lower spermidine and spermine levels were associated with higher cardiovascular disease-related mortality rate.

10.5539/gjhs.v4n6p170

Several studies have found that luteolin supports heart health. Studies in mice have shown that luteolin strengthens heart cells and heart contractions.

10.1371/journal.pone.0082957

PMID: 2172327

Luteolin was found to reduce oxidative stress-induced damage during a simulated heart attack in the isolated hearts of mice.

https://doi.org/10.1007/s11655-015-2296-x

In a human study, quercetin lowered LDL oxidation, increased levels of which are associated with coronary heart disease, amongst male participants.

10.1016/j.imbio.2010.07.011

Research including hypertensive human participants suggests that quercetin is able to reduce blood pressure, thereby supporting cardiovascular health.

10.1093/jn/137.11.2405

Dihydroquercetin has been shown to promote heart health in healthy human volunteers via lowering LDL cholesterol.

https://doi.org/10.1016/j.ejphar.2012.03.035

Brain

In several animal and organism models, supplementation with spermidine has been shown to protect against neurodegeneration.

10.1172/JCI73944

10.1038/nature05292 

In mice, spermidine was also shown to reduce dementia (in a mouse model of frontotemporal lobar dementia).

10.1073/pnas.1206362109

Across various animal and cell studies, luteolin has been shown to have neuroprotective effects and to support nerve development. This effect is likely due to luteolin’s ability to reduce glutamate levels, suppress brain inflammation and deter oxidative stress. These benefits support hippocampal neuron growth and prevent the mutation of neural proteins.

Inflammation

In animal studies, luteolin has been shown to prevent inflammation of the lungs, nose and brain via the inhibition of pro-inflammatory cytokines.

In mice, luteolin also prevents viral-induced inflammation in the breast and lung.

Quercetin and its derivatives ability to fight inflammation, as well as to activate NrF2, increase glutathione levels, and scavenge free radicals, is one of its main mechanisms of conferring health benefits.

https://doi.org/10.5114/ceji.2017.67315

doi:10.18632/oncotarget.16092

https://doi.org/10.1016/j.neuro.2016.05.008

https://doi.org/10.1016/j.brainresbull.2015.09.002

Immunity

Luteolin supplementation has been shown to enhance the immune system in various ways. In animal studies, luteolin blocks lipopolysaccharide-induced (LPS) inflammation which is associated with bacterial infection.

Luteolin has also been found to inhibit viral spread in mice, including both Epstein-Barr and hepatitis B . A cell study also supports this evidence, suggesting that luteolin has antiviral capacities against Japanese encephalitis virus.

https://doi.org/10.1007/978-90-481-9078-2_1

PMID:11123379

https://doi.org/10.2174/138161206778743565

https://doi.org/10.1164/ajrccm.165.6.2101049

https://doi.org/10.1016/j.antiviral.2016.05.007

https://doi.org/10.18632/oncotarget.7967

https://doi.org/10.1021/acs.molpharmaceut.5b00789

Lifespan

In animal and organism models, spermidine supplementation extends lifespan.

10.1038/ncb1975

PMID: 28407698

10.1083/jcb.201008167

10.1038/cdd.2016.71

One study showed that in several Asian countries, the amount of polyamine uptake via food is correlated with life expectancy, however confounding factors in this study were not adequately adjusted for.

10.4236/health.2010.212206

In nonagenarians(90-99 y.o) and centenarians, an increase in levels of whole-level spermidine is linked to longevity.

PMID: 22950434

When blood levels of spermidine are increased in aged mice via supplementation of polyamine-producing probiotic bifidobacteria, decreased mortality is observed.

10.1038/srep04548

10.1371/journal.pone.0023652

Weight

In a study, spermidine was shown to reduce weight gain and certain risk factors of obesity.

10.1038/cddis.2017.373

Hair

In multiple studies, spermidine has been shown to improve hair growth, hair follicle number and hair follicle health in ‘hair follicle epithelial stem cells in serum-free organ culture’.

10.1371/journal.pone.0022564

https://doi.org/10.5826/dpc.0704a05

Skin

Animal research has found that luteolin may reverse skin aging and prevent the development of skin cancer. This effect is likely due to the antioxidative properties of luteolin, which protect the skin from sun damage. 

https://doi.org/10.1111/jcmm.12050

https://doi.org/10.1158/0008-5472.CAN-09-4093

Muscle

In aged mice, spermidine administration was able to prevent the senescence of muscle stem cells, improve muscle regeneration, and inhibit muscle atrophy.

PMID:28407698

10.1038/nature16187

In collagen-deficient mice, spermidine aided with improving muscle defects.

10.1080/15548627.2015.1108508

In mice quercetin supplementation has been shown to reduce muscle mass atrophy.

https://doi.org/10.1155/2014/83429

In a human study with young athletes, quercetin supplementation increased muscle mass.

https://doi.org/10.1186/s12970-019-0303-x

Mitochondria

Overall, spermidine has been shown to improve mitochondria health and structure in both cardiac and skeletal muscles in mice.

10.1080/15548627.2015.1108508

10.1038/nm.4222

PMID: 28407698

10.1038/nature16187

A study in vitro showed that quercetin reduced renal tubular epithelial cell senescence likely via activating SIRT-1 and inducing mitophagy, the beneficial clearing of damaged mitochondria.

https://doi.org/10.1016/j.lfs.2020.118116

In mice, quercetin improves mitochondrial biogenesis in the brain and muscle – therefore quercetin possesses the ability to both clear out damaged mitochondria and stimulate the generation of new functional mitochondria.

https://doi.org/10.1152/ajpregu.90925.2008.

Mimetic

Spermidine is also considered a calorie-restriction mimetic, meaning that it is thought to mimic the health benefits of calorie restriction(CR)(enhanced longevity) by impacting similar mechanisms as CR. One of the main health-promoting mechanisms of CR is autophagy, which clears cells of damage, and is critical for cellular homeostasis as well as preventing cells from going awol.

10.4161/15384101.2014.973309

  • Spermidine

    It is a polyamine, meaning that it is an organic compound with two or more amino groups. Spermidine plays a crucial role in the survival and function of cells, including supporting cellular growth, DNA health, and apoptosis 💥

  • Luteolin

    Luteolin is a plant pigment belonging to the flavonoid family. Supplementation with luteolin is believed to confer longevity benefits, as it has multiple biological effects such as anti-inflammation, anti-allergy and anti-cancer, luteolin functions as either an antioxidant or a pro-oxidant biochemically ⭐️

  • Dihydroquercetin

    A plant flavonoid phytochemical compound derived from quercetin. Dihydroquercetin has higher absorption and bioavailability when compared to quercetin - it is able to enter the bloodstream faster. Research shows that quercetin in part impacts cellular senescence, loss of proteostasis, and mitochondrial dysfunction ⚡️

  • Always Tested

    We pride ourselves on transparency - we conduct third-party lab tests on all batches we manufacture to validate the ingredients we use are pure. Therefore, offering the highest quality products.

  • Cold Storage

    We keep our inventory in custom built refrigeration in our warehouse to ensure your product isn't sitting on the shelf for months on end in a hot warehouse, potentially degrading.

FAQ

Why does Clean Being use dihydroquercetin and not regular quercetin?

Dihydroquercetin has higher absorption and bioavailability when compared to quercetin - it is able to enter the bloodstream faster.

What is autophagy?

Autophagy is a cellular clean-up, salvage and recycling mechanism which removes damaged cells (including diseased cells) and cellular parts, in order to promote the proper functioning of cells.

Why is autophagy important?

 If autophagy is dysregulated this can lead to oxidative stress, chronic inflammation and disease. As we age, autophagy declines. Therefore, in order to prevent the processes of aging, diseases of aging and to ensure optimal cellular function, supporting proper regulation of autophagy is important. 

What is apoptosis?

Apoptosis is a necessary cellular process to end a cell's life; it is known as ‘programmed cell death’.

This built-in cellular process is necessary to eliminate dysfunctional cells and make way for new healthy cells.

Certain pro-aging cells can develop resistance to apoptosis, such as senescent cells (contribute to disease) and cancer cells. Thus, when apoptosis is not effective, dysfunctional cells can replicate and cancer may develop.

Why is apoptosis important?

The dysregulation of cellular death likely accelerates the aging processes. To support healthy apoptosis, look into fasting, and phytochemicals like: luteolin, NMN, resveratrol, spermidine and sulforaphane. 

Where are your products made?

We manufacture in an FDA registered and GMP certified facility in the USA.

What about dosage?

We recommend taking 2 capsules a day with food, preferably containing some fat.

Is Clean Being vegan and/or gluten free?

Yes, Clean Being is vegan and gluten free 🌱.

What are some healthy fats I can take my Clean Being capsules with?

We recommend taking Clean Being with moderate fats, as quercetin's bioavailability improves when done so.

Examples include, but are not limited to: avocado, MCT oil, coconut oil, eggs, yogurt, butter, nuts, and salmon.