The Importance of NAD+

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that is found in all living cells. It is important for a number of chemical reactions that occur in the body, including energy metabolism, DNA repair, and the regulation of enzyme activity. It is also involved in processes that help to maintain the integrity of DNA, and it can help to regulate the activity of certain enzymes that are involved in important biological functions. As we age, the levels of NAD+ in our cells decline, which can lead to a number of age-related diseases and conditions.

Maintaining healthy levels of NAD+ may help to reduce the risk of these diseases and promote overall health and well-being.

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  • a chart showing NAD levels rapidly declining from 0-80 years old

    NAD+ Declines with Aging

    NAD+ levels decrease with age (~50% every 20 years) and these levels are directly correlated with a number of age-related conditions and neurodegenerative disease. A decline in NAD+ results in a decrease in energy metabolism, weakened DNA repair, and inefficient immune activation. Sirtuins, a class of longevity enzymes that regulate and control genes rely on NAD+ to guide them to do their functions. Consequently, as levels decline, sirtuins aren’t optimally guided to do their jobs to repair and maintain the body for peak health and performance. If there isn't enough NAD+ to guide sirtuins to maintain cellular identity, skin cells start to act like nerve cells, nerve cells start to act like kidney cells, etc. – the body is confused. This explains why the body breaks down with old age and consequently wrinkles appear, there will be less benefit from exercise, energy levels decline, constant fatigue and compromised mitochondrial function occurs.

  • a chart of NAD levels in humans increasing over 4 weeks

    Increase NAD+ with Cell Being

    Cell Being is a synergistic mix of molecules that support the production of cellular energy to promote DNA repair and maintain metabolic homeostasis by increasing NAD+ levels. Formulated with the direct precursor to NAD+, which means that it converts into NAD+ in the cell. We paired this immediate precursor with potent extract from japanese knotweed because they work synergistically to further enhance sirtuin activation, amplifying the beneficial effects on cellular health. Then we added TMG (betaine) to improve methylation pathways to potentially avoid depleting methyl groups from increased NAD+ production. It has also been used primarily to optimize athletic performance and to improve heart health.

In the spotlight

Almost everyone who is keen to learn more about aging, longevity and fasting has read or watched David Sinclair’s books, articles, and videos.

It’s important to say that VERSO® is not affiliated with David Sinclair or any of his work, and doesn’t endorse any specific brands. We’re part of the community inspired by his research, and our own scientific research and development of Cell Being and Clean Being supplements finds its roots with him.

David Sinclair is a well-renowned biologist, professor of genetics [1], and co-director for Biology of Aging Research at Harvard Medical School [2]. He’s best known for his pioneering focus on epigenetics, which informed and led to his worldwide best-selling book, Lifespan: Why We Age—and Why We Don't Have To.

  • NAD+ Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

    Administration safely increased circulating NAD levels, and significantly reduced total LDL and non-HDL cholesterol, body weight, and diastolic blood pressure.

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  • NAD+ Repletion Rescues Female Fertility during Reproductive Aging

    Treatment with the immediate NAD+ precursor rejuvenates oocyte quality in aged animals, leading to restoration in fertility.

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  • Neuroprotective effects of the immediate NAD+ precursor in a photoreceptor degenerative model of retinal detachment

    NAD+ precursor administration exerts neuroprotective effects on photoreceptors after retinal detachment and oxidative injury.

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    read the study →

  • Watch this summary of Dr. David Sinclair's work by Thomas Delauer

    Longevity is difficult to talk about and it’s difficult to research. What people think of as longevity isn’t necessarily what it really is...

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    read the study →

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